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[(m)-10.2(e)0(n)-9.6(t)-304(fo)-9.6(r)-297.9(a)0(p)-13.5(p)-7.7(ro)-9.8(xi)-12(ma)-9.7(tel)-16.5(y)-295.3(1)0(5)-308.8(d)0(i)-12.9(a)0(g)-10.3(nos)-13.8(es)-304.7(\(C)-13.3(en)-9.6(te)-13(r)-7(s)-7.6(,)-300.1(200)-11.2(6;)-305.9(Ge)-11.3(s)-7.6(e)0(l)-9.8(l)0(,)]TJ
0 -1.2203 TD
[(20)-11.7(09)-11.7(\).)-199.4(HB)-9.3(OT)-195.7(h)-9.7(a)0(s)-196.8(n)0(o)-12.5(t)-190.2(be)-10.6(en)-199.3(ap)-7.2(p)-7.7(l)0(i)-13.4(e)0(d)-198.9(t)0(o)-199.3(P)0(T)-10.7(S)0(D)-195.9(t)0(o)-199.3(o)0(u)-10.5(r)-190.4(kn)-14.1(ow)-10.7(le)-9.8(dg)-7.4(e,)]TJ
T*
[(w)-7.9(h)0(i)-13.2(l)0(e)-288(t)0(h)-10.2(e)-284.4(ev)-13.3(ide)-12.8(n)-9.7(c)0(e)-290(f)0(o)-9.6(r)-285.2(it)-10.3(s)-285.8(eff)-13.5(ec)-11.8(ti)-10.3(v)-7.1(e)0(n)-9.6(e)0(s)-13.9(s)-279.5(i)-9.9(n)-281.6(P)-7.7(C)0(S)-289.5(i)0(s)-289.4(s)-7.6(can)-14.8(t.)-287.9(Si)-8.3(n)-9.7(c)0(e)]TJ
T*
[(19)-11.7(89)-416.3(w)-7.9(e)-410.9(an)-9.2(d)-414(o)0(t)-9.6(h)0(e)-9.6(r)-7(s)-412.3(h)0(a)-9.2(v)-7.1(e)-410.9(inv)-14(es)-13.9(ti)-10.3(ga)-10.3(te)-13(d)-407.7(t)0(h)-10.2(e)-417.2(ap)-7.2(p)-7.7(l)0(i)-7.1(c)0(a)-11.4(t)0(i)-10.3(o)-9.1(n)-408.1(o)-9.1(f)-411.5(a)]TJ
0 -1.2266 TD
[(l)-9.9(o)0(w)-10.7(er-)-13.7(p)-7.7(r)-7(ess)-15.2(ur)-8.4(e)-195.9(p)0(r)-8.4(o)0(t)-9.6(o)-9.1(co)-8.4(l)-193.2(o)0(f)-199.3(H)0(B)-9.3(OT,)-198.7(HB)-9.3(O)-9.4(T)-192.7(1.)-8.8(5)-189.2(A)-7.7(TA)-10.7(,)-192.6(t)0(o)-192.9(p)-7.7(at)-12.6(ie)-9.8(nt)-10.2(s)]TJ
0 -1.2203 TD
[(w)-7.9(i)0(t)-10.3(h)-528.2(a)-530.6(var)-13.6(ie)-9.7(ty)-536(of)-534.4(ch)-9(r)-7(o)0(n)-12.5(i)0(c)-533.9(n)0(e)-9.6(u)-7.7(ro)-9.8(lo)-12.6(gi)-7.9(ca)-11.4(l)-528.3(dis)-14.2(or)-9.8(de)-9.2(r)-7(s)-526.1(\(G)-11.9(o)-9.1(lde)-12.8(n)]TJ
T*
[(et)-443(al)-9.4(.)-9.2(,)-432.9(20)-11.7(02;)-438.2(Ha)-12.1(r)-7(c)0(h)-438.9(a)0(n)-15.5(d)-433(Ne)-12.5(uba)-11.6(u)-7.7(e)0(r)-13.2(,)-432.9(19)-11.7(99,)-14.6(200)-11.2(4a)-11.7(,2)-8.7(00)-11.7(9b)-10.3(,2)-8.8(00)-11.7(9c;)]TJ
0 -1.2266 TD
[(Ha)-12.1(r)-7(c)0(h)-407.3(e)0(t)-405(a)0(l)-9.4(.)0(,)-404.2(1)0(9)-11.7(9)0(4)-11.7(,)-394.9(19)-11.7(96)-11.7(a;)-407.1(Neu)-13.9(ba)-10.3(u)-7.7(e)0(r)-405.3(e)0(t)-405(a)0(l)-9.4(.)-9.2(,)-394.9(1)0(9)-11.7(9)0(4)-11.7(\))0(,)-401.7(b)-10.7(as)-7.1(ed)-407.6(on)]TJ
0 -1.2203 TD
[(i)-9.9(nit)-13.7(ia)-9.4(l)-357.6(s)-7.6(tu)-8.1(d)-9.3(i)0(e)-9.8(s)-355.4(do)-12.1(ne)-363.7(by)-362.9(Ne)-12.5(uba)-11.6(u)-7.7(e)0(r)-361(\()0(N)-13.1(eub)-18.3(au)-7.2(er)-361(et)-367.1(al)-9.4(.,)-359.9(19)-11.7(90)-11.7(\))-354.6(i)0(n)]TJ
T*
[(ch)-15.3(ro)-9.8(ni)-13.2(c)-233.2(s)-7.6(tro)-16.6(ke)-10.6(.)-230.5(F)0(e)-10.6(w)-235.6(o)-9.1(f)-234.4(th)-10.2(e)-240.2(c)0(h)-9(r)-7(oni)-16(c)-233.2(T)0(B)-12.3(I)-236.1(pa)-7.2(ti)-10.3(en)-15.9(ts)-242.1(ha)-9.2(d)-237(P)0(C)-7.8(S)-238.7(fro)-16.6(m)]TJ
0 -1.2266 TD
[(m)-10.2(i)0(l)-7.1(d)-559.4(TBI)-14.4(,)-553(b)0(l)-14.3(a)0(s)-7.1(t)0(-)-13.6(ind)-16.2(uce)-13.2(d)-559.4(P)0(C)-7.8(S)0(,)-564.1(o)0(r)-559.9(b)0(l)-14.3(a)0(s)-7.1(t)0(-)-13.6(ind)-16.2(uce)-13.2(d)-559.4(P)-7.7(CS)-561.4(wit)-12(h)]TJ
0 -1.2203 TD
[(P)-7.7(T)0(S)-14.1(D)0(.)-200.3(W)0(e)-201.3(p)-7.7(u)-7.7(b)0(l)-8(i)0(s)-11.2(h)0(e)-9.6(d)-199(th)-10.2(e)-202.2()0(r)-10(s)0(t)-204.1(a)0(p)-7.2(p)-7.7(li)-7.1(ca)-11.4(ti)-10.3(o)-9.1(n)-199.4(of)-199.3(HB)-15.6(OT)-202.1(1.)-8.8(5)-195.5(A)-7.7(TA)-200.4(to)]TJ
T*
[(ch)-15.3(ro)-9.8(ni)-13.2(c)-422.9(b)0(l)-7.9(a)0(s)-13.5(t)0(-)-13.6(ind)-16.2(uce)-13.2(d)-426.6(P)-7.7(CS)-428.6(w)-7.9(i)0(t)-10.3(h)-427(PT)-10.7(SD)-429.8(in)-430.6(20)-11.7(09)-429(\(H)-13.1(arc)-12.1(h)-427(a)0(n)-9.2(d)]TJ
0 -1.2266 TD
[(Fo)-13.5(ga)-10.3(r)-7(t)0(y)-11.2(,)-281.1(20)-11.7(09)-11.7(a\).)]TJ
1.1128 -1.2203 TD
[(Oxygen)-245(toxicity)-250.6(\(Clark,)-245.7(1993;)-247.6(U.S.)-246(Navy,)-247.8(2008\))-245.1(is)-245.1(a)-246.1(concern)]TJ
-1.1128 -1.2203 TD
[(in)-228.2(any)-228.6(HBOT)-224(study.)-228.5(The)-227.6(most)-223.4(severe)-230.1(manifestation)-230.8(is)-226.1(seizure.)]TJ
T*
[(A)-273.3(study)-276.1(of)-275.1(HBOT)-274.6(on)-271.7(sub-acute)-273.6(moderate)-275.7(to)-275.1(severe)-274.3(TBI)-273.7(at)-271.9(2.0)]TJ
0 -1.2266 TD
[(ATA)-220.8(\(Lin)-212.7(et)-215.3(al.,)-217.5(2008\))-213.5(reported)-223.8(a)-214.5(9)0(%)-209.8(seizure)-221.2(rate.)-218.5(At)-216.8(doses)-217(less)]TJ
0 -1.2203 TD
[(than)-215.4(2.0)-204.3(ATA,)-211.1(side)-210.1(effects)-216.8(and)-208.2(toxicity)-212.6(in)-209.2(chronic)-214.7(brain)-207.6(injured)]TJ
T*
[(patients)-490.5(have)-490.4(been)-488.1(noted)-490.1(only)-488.3(with)-489.6(prolonged)-489.7(courses)-487.2(of)]TJ
0 -1.2266 TD
[(HBOT)-280.9(\(i.e.,)-284.5(70500)-281.6(treatments)-281.9([Harch,)-284.5(2002]\).)]TJ
1.1128 -1.2203 TD
[(We)-220.2(report)-227.2(the)-225.1(safe)-222.5(application)-220.6(of)-224.5(a)-220.8(29-day)-221.4(treatment)-223.7(course)]TJ
-1.1128 -1.2203 TD
[(of)-344.7(1.5)-337.1(ATA)-347.2(HBOT)-337.8(to)-344.7(16)-340.5(U.S.)-340.8(servicemen)-341.3(with)-344.1(mild)-342.7(to)-338.4(mod-)]TJ
0 -1.2266 TD
[(erate)-379.9(blast-induced)-383.6(PCS,)-376(or)-376.5(PCS)-373.1(with)-382.1(PTSD,)-373.9(and)-379(note)-379.6(a)-372.6(bi-)]TJ
0 -1.2203 TD
[(phasic)-311.9(response,)-310.7(with)-312.5(transient)-316.2(worsening)-311.9(of)-306.7(symptoms)-310.3(in)-310.4(4)]TJ
T*
[(of)-464.8(the)-459(16)-460.6(subjects,)-458.5(followed)-466.5(by)-457.8(improvement)-463.1(as)-462.4(treatment)]TJ
T*
[(continued.)-374.1(These)-367.9(veterans)-366.3(experienced)-373.4(symptomatic,)-371.6(physi-)]TJ
0 -1.2266 TD
[(cal,)-277.1(cognitive,)-273.9(affective,)-279.1(and)-277.8(brain)-270.8(blood)-275.7(ow)-273(improvements.)]TJ
/F3 1 Tf
0 -2.4406 TD
(Methods)Tj
/F9 1 Tf
0 -1.8336 TD
[(Study)-338.6(design)-330.3(and)-335.7(protocol)]TJ
/F4 1 Tf
1.1128 -1.8336 TD
[(The)-290.8(design)-287.4(is)-289.4(a)-284(pilot)-289.9(proof-of-concept)-296.9(study)-288.8(with)-287.2(pre-)-293.3(and)]TJ
-1.1128 -1.2266 TD
[(post-testing)-323.4(and)-315.7(no)-316(control)-316.4(group.)-317(Subjects)-320(completed)-317.6(a)-315.7(his-)]TJ
0 -1.2203 TD
[(tory)-337.2(and)-334.7(physical)-338.8(exam)-334.2(by)-331.3(the)-338.9(P.I.,)-334.7(clinical)-331.7(interview)-342.6(by)-331.3(the)]TJ
T*
[(neuropsychologist,)-867.9(psychometric)-861.3(testing,)-857.4(symptom)-859.1(and)]TJ
0 -1.2266 TD
[(quality-of-life)-205.9(questionnaires,)-205.5(baseline)-198.9(single)-199.4(photon)-197.5(emission)]TJ
0 -1.2203 TD
[(computed)-467.3(tomography)-460(\(SPECT\),)-465.1(rst)-460.7(HBOT)-458(the)-459(following)]TJ
T*
[(day,)-490.4(and)-486.4(repeat)-488.7(SPECT)-486.6(3)-170.2(h)-483.9(after)-494.2(the)-484.3(rst)-492.3(HBOT.)-486.2(Subjects)]TJ
T*
[(commenced)-438.9(twice/day,)-428.7(5)-435.8(day/week)-433.1(1.5)-431.9(ATA/60)-165.9(min)-434.4(total)]TJ
0 -1.2266 TD
[(dive)-456.1(time)-450.4(HBOT)-451.6(until)-448.6(40)-448(HBOT)-451.6(sessions)-457.5(were)-451(completed.)]TJ
0 -1.2203 TD
[(Within)-367.4(5)-359.9(days)-362.3(of)-357.3(nal)-363.5(HBOT)-363.1(subjects)-360.8(underwent)-367.8(repeat)-362.2(fo-)]TJ
T*
[(cused)-529.7(history,)-531.7(physical)-528.5(exam,)-526.9(psychometric)-532.5(testing,)-534.9(ques-)]TJ
0 -1.2267 TD
[(tionnaires,)-287(and)-284.1(SPECT.)]TJ
/F9 1 Tf
28.0042 74.5598 TD
[(Inclusion)-330.3(criteria)]TJ
/F4 1 Tf
1.1128 -1.8336 TD
[(Subjects)-187.2(had)-189.3(to)-192.9(be)-187.7(1865)-187.2(years)-189.2(old,)-189.3(with)-192.4(one)-189.4(or)-186.8(more)-190.6(mild)-191(to)]TJ
-1.1128 -1.2203 TD
[(moderate)-301(TBIs)-306.6(characterized)-305.9(by)-299.7(loss)-299.8(of)-306.7(consciousness)-305.5(due)-307.8(to)]TJ
0 -1.2266 TD
[(blast)-312.7(injury)-315.5(that)-313.7(was)-312.3(a)-309.3(minimum)-314.3(of)-313.1(1)-315.7(year)-308(old)-312.8(and)-315.7(occurred)]TJ
0 -1.2203 TD
[(after)-291.9(9/11/01.)-291(They)-295.2(had)-290.4(to)-294.1(have)-294.4(a)-296.7(prior)-293.6(diagnosis)-294.7(of)-294.1(chronic)]TJ
T*
[(TBI/PCS)-194.5(or)-186.8(TBI/PCS/PTSD)-195.4(by)-192.2(military)-196.6(or)-186.8(civilian)-194.1(specialists,)]TJ
0 -1.2266 TD
[(with)-261.9(an)-262.1(absence)-260.6(of)-262.5(acute)-259.8(cardiac)-264.1(arrest)-261.8(or)-256.4(hemorrhagic)-268.1(shock)]TJ
0 -1.2203 TD
[(at)-360.4(the)-364.2(time)-368.2(of)-363.6(TBI,)-365.1(Disability)-360.8(Rating)-369.6(Scale)-361.1(score)-364.4(\(Rappaport)]TJ
T*
[(et)-253.3(al.,)-249.1(1982\))-251.4(of)-256.2(03,)-248(negative)-258.4(urine)-249.1(toxicology)-260.1(screen)-251.1(for)-256.9(drugs)]TJ
T*
[(of)-268.8(abuse,)-275(negative)-271.1(pregnancy)-275.6(test)-274(in)-266.2(females,)-277(otherwise)-272.8(good)]TJ
0 -1.2266 TD
[(health,)-455.7(and)-454.8(less)-455(than)-462(90%)-449.6(on)-461.4(the)-452.7(Percent)-460.2(Back)-455.1(to)-458.5(Normal)]TJ
0 -1.2203 TD
[(Rating)-281.1(Scale)-278.9(\(PBNRS;)-288.7(Powell)-278.3(et)-284.9(al.,)-280.8(2001\).)]TJ
/F9 1 Tf
0 -2.447 TD
[(Exclusion)-332.5(criteria)]TJ
/F4 1 Tf
1.1128 -1.8336 TD
[(Subjects)-370.6(were)-368.9(screened)-374.1(out)-371.3(of)-370(the)-376.8(study)-371(with)-369.4(pulmonary)]TJ
-1.1128 -1.2203 TD
[(disease)-293(that)-301(precludes)-294.9(HBOT)-299.9(\(e.g.,)-291.7(bronchospasm)-302.3(unrespon-)]TJ
T*
[(sive)-277.4(to)-281.4(medication)-284.8(or)-281.7(bullous)-277.5(emphysema\),)-286.5(unstable)-279.5(medical)]TJ
0 -1.2266 TD
[(conditions)-529.3(that)-522.3(are)-524.9(contraindicated)-527.6(in)-525.4(HBOT)-521.2(\(e.g.,)-525.7(severe)]TJ
0 -1.2203 TD
[(congestive)-483.6(heart)-484.5(failure)-483.2(or)-484(heart)-484.5(failure)-483.2(requiring)-483.5(hospital)]TJ
T*
[(emergency)-477.4(evaluation)-476.3(or)-471.4(admission)-471.2(in)-474.8(the)-478(previous)-473.2(year\),)]TJ
T*
[(severe)-331.2(connement)-335.5(anxiety)-335.8(\(e.g.,)-336(patients)-332.4(who)-330.3(require)-339.3(anes-)]TJ
0 -1.2266 TD
[(thesia)-204.1(or)-205.8(conscious)-211(sedation)-209.9(for)-206.3(MRI\),)-210.9(participation)-209.1(in)-202.9(another)]TJ
0 -1.2203 TD
[(experimental)-296.4(trial)-292.3(with)-293.5(active)-288(interventions,)-298.3(high)-292.9(probability)]TJ
T*
[(of)-376.3(inability)-374.1(to)-376.3(complete)-377.8(the)-376.8(experimental)-378.6(protocol)-380.4(\(e.g.,)-373.9(ter-)]TJ
0 -1.2266 TD
[(minal)-349(condition\),)-348(previous)-353.1(HBOT,)-347.1(history)-345.4(of)-351(hospitalization)]TJ
0 -1.2203 TD
[(for)-339.1(past)-337.8(TBI,)-339.8(stroke,)-341.3(non-febrile)-344.9(seizures,)-345.6(or)-338.6(any)-336.1(seizure)-341.3(his-)]TJ
T*
[(tory)-432(other)-437.2(than)-436.7(seizure)-442.5(at)-429.9(the)-440(time)-431.4(of)-439.5(TBI,)-434.7(past)-432.6(or)-439.8(current)]TJ
0 -1.2266 TD
[(history)-345.4(of)-344.7(mental)-352.1(retardation)-349.1(\(baseline)-344.8(full-scale)-348(intelligence)]TJ
0 -1.2203 TD
[(quotient)-275.5([FSIQ])-274.6(score)]TJ
/F5 1 Tf
9.7183 0 TD
()Tj
/F4 1 Tf
.7208 0 TD
[(70\),)-274.3(alcohol)-274(or)-275.4(drug)-275(abuse)-272.1(\()-82.7(Michigan)]TJ
-10.4391 -1.2203 TD
[(Alcohol)-200(Screening)-202.7(Test)-200.7([MAST])-204.9(or)-199.5(Drug)-197.6(Abuse)-204.4(Screening)-202.7(Test)]TJ
0 -1.2266 TD
[(score)-294.8([DAST])]TJ
/F5 1 Tf
6.3103 0 TD
(>)Tj
/F4 1 Tf
.7145 0 TD
[(3\),)-293.8(or)-294.3(pre-)-293.3(or)-288(post-TBI)-299(history)-294.8(of)-287.8(systemic)-298.7(ill-)]TJ
-7.0247 -1.2203 TD
[(ness)-284.1(with)-280.9(impact)-279.9(on)-284.4(the)-282(CNS)-276.8(\(per)-287(P.I.)-281.2(decision\).)]TJ
/F9 1 Tf
0 -2.4406 TD
[(Symptom)-335.5(and)-329.4(physical)-334.5(exam)-332.4(scoring)]TJ
/F4 1 Tf
1.1128 -1.8336 TD
[(Subjects)-459.1(constructed)-467.2(a)-461.1(prioritized)-461.6(symptom)-460.7(list)-464.1(and)-461.2(an-)]TJ
-1.1128 -1.2266 TD
[(swered)-411.1(neurological)-410.4(and)-410.6(constitutional)-417.8(symptom)-410.1(questions)]TJ
0 -1.2203 TD
[(from)-418.8(the)-414.7(P.I.s)-417.2(standard)-421.9(questionnaire)-422.5(\(see)-418.9(Appendix\).)-417.8(Ab-)]TJ
T*
[(normal)-405.8(components)-416.9(of)-407.9(the)-408.4(physical)-408.4(exam)-410.1(were)-406.8(videotaped)]TJ
0 -1.2266 TD
[(and)-524.4(then)-525.6(replayed)-530.8(before)-526.6(the)-528.6(nal)-521.6(exam)-530.3(after)-525.9(HBOT)-527.5(for)]TJ
0 -1.2203 TD
[(comparison.)-255.4(After)-255.8(the)-250.3(40th)-255.8(HBOT)-255.6(session,)-250.4(subjects)-259.6(judged)-250.6(all)]TJ
T*
[(symptoms)-183.8(as)-184.2()55(better,)50.7()-178.9()55(worse,)50.2()-185.2(o)0(r)-180.5()55(same,)51.9()-178.9(and)-182.9(the)-187.1(P.I.)-180(did)-186.6(the)]TJ
0 -1.2267 TD
[(same)-301.8(for)-307.4(the)-307.3(physical)-313.5(exam)-302.6(abnormalities.)-307.6(Exam)-305.7(items)-312.6(inad-)]TJ
0 -1.2203 TD
[(vertently)-260.1(omitted)-260.6(on)-252.8(retesting)-260.7(were)-261.4(scored)-259.9(as)-253.7(unchanged.)-260.8(Six)]TJ
T*
[(months)-356.7(following)-354.8(the)-351.5(last)-352.6(HBOT)-356.8(session)-355(subjects)-354.4(were)-356.2(que-)]TJ
T*
[(ried)-323.3(by)-325(phone)-327(about)-324.7(the)-326.2(status)-326.9(of)-325.7(their)-324.1(prioritized)-328.8(symptom)]TJ
0 -1.2266 TD
[(list.)-327.9(Each)-334(subject)-334.2(was)-331.2(asked)-330.6(to)-332(rate)-335.7(each)-330.9(symptom)-334.3(as)-329.6(better,)]TJ
0 -1.2203 TD
[(worse,)-325.4(or)-325.9(the)-326.2(same)-327.1(compared)-332.9(to)-325.7(the)-326.2(status)-326.9(of)-332(that)-326.3(symptom)]TJ
T*
[(before)-280(HBOT.)]TJ
/F9 1 Tf
0 -2.447 TD
[(Psychometric)-335.9(testing)]TJ
/F4 1 Tf
1.1128 -1.8336 TD
[(Table)-225.3(1)-233.5(lists)-231.5(neuropsychological)-239.6(and)-233.5(psychological,)-234.4(quality)]TJ
-1.1128 -1.2203 TD
[(of)-433.2(life,)-440.3(screening)-439.4(and)-429.5(diagnostic)-438.5(tests,)-442.7(and)-435.9(the)-433.7(schedule)-441.6(of)]TJ
0 -1.2266 TD
[(administration.)-291.2(The)-290.8(choice)-299(of)-287.8(tests)-294.3(was)-287(guided)-293.4(by)-293.4(past)-287.2(expe-)]TJ
0 -1.2203 TD
[(rience)-284.9(with)-287.2(pre-)-287(and)-284.1(post-testing)-291.8(for)-288.5(HBOT)-280.9(effects)-292.7(in)-285.1(chronic)]TJ
T*
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